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Basic research

Development of new active ingredient

People's demand for effectiveness and utility increases each day, therefore it is essential for products to introduce latest technology. Thus Fundamental Research Division develops innovative technology for phenomena occurred with advancing age and/or circumstances such as age spot, dull skin, wrinkle, and dry skin by cooperating with other companies and universities.
We succeeded developing novelty functional materials from our previous researches. Moreover, by biochemically analyzing those materials we are now able to offer an effective formula for anti-aging.
We continue developing new active ingredients to be able to offer new possibilities.

RT-POR Apparatus
There are some cases in the assessment of genetic-level that a small amount of gene sequences in vivo should specifically increase.
This apparatus (Polymerase Chain Reaction) is applied to above cases.
Freeze dryer
Freeze drying is a popular method in food industry. Since it dries samples on freeze condition, it enables to maintain vitamin C without changing its component. Moreover, by freeze drying, we receive the advantages of increase solubility and back to the original state by just adding water.
Diffusion cell of percutaneous absorption test
Assess metabolic and permeability of active ingredients to the skin by using 3-dimensional cultured skin model.

A novel amphiphilic vitamin C derivative Funcos C-IS

L-Ascorbic acid (vitamin C) is known to be a neutral bioactive agent, and its multifarious activities in many biological systems have been reported. For example, vitamin C increases enzyme activity acts as an inducer of the collagen pathway and scavenges free radicals as an antioxidant during oxidant stress. However, Vitamin C is less resistant to heat and oxidative conditions than other vitamins are, and is easily decomposed in cosmetics. To solve this problem, numerous stable derivatives of vitamin C have been developed.

Among these derivatives, L-ascorbic acid 2-phosphate sodium and magnesium salt are hydrophilic derivatives, and ascorbyl tetraisopalmitate was a lipophilic derivative. These are already available as an additive in commercial cosmetics. However, these derivatives have lower skin permeability and metabolism to vitamin C.

We developed a novel amphiphilic ascorbic derivative, Funcos C-IS, which exhibits satisfactory thermal stability. Funcos C-IS improved skin permeability superior to those of vitamin C, and is susceptible to enzymatic hydrolysis by phosphatase to produce VC. Thus, these finding indicated that Funcos C-IS may be effective pro-Vitamin C in skin care. In closing, we expected that Funcos C-IS with the characteristic properties is utilized in not only skin-care field but also make-up fields.

  • INCI: Disodium Isostearyl Ascorbyl Phosphate
  • Add 4 concepts to the Vitamin C and realize your 'more to the place where necessary' Vitamin C, High Stability, High vital stability, High skin penetrate ability, High vitamin C feeding ability
Relevant Patents Japan/Patent No. 4190539
The USA/ Patent No.7282597
Korea/Patent No.10-0719777
Singapore/Patent No.125273
Conference Presentation 16th IFSCC Conference in Florence
24th IFSCC Congress in Osaka

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About environmental activities that we work on
Acquiring environmental management system, "ISO14001" certification.
Acquiring quality management system, "ISO9001" certification.
We acquired certification for "ISO 22716" of Cosmetic GMP Guideline.
We received "Osaka's Excellent Manufacturing Company Prize" from the Osaka Prefectural Government.

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